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Search Results to Robert Corwine Roach Jr.

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Roach Jr., Robert

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My research focuses on the broad area of human responses to hypoxia. Current research is focused on three major areas: cerebrovascular hemodynamics in hypoxia and exercise; transcriptomic prediction of human responses to hypoxia; and the integration of systems biology with integrative, whole body physiology to understand the molecular and cellular mechanisms of oxygen sensing in humans. Cerebrovascular Hemodynamics: We have recently shown that hypoxia impairs cerebral autoregulation; research is underway to begin to understand the importance of this finding and its possible mechanisms. Prediction of Human Responses to Hypoxia: We found that a gene expression signature from a blood sample collected in Denver predicted >95% of those who later developed acute mountain sickness. A recent validation study at lower altitudes in a more diverse population confirmed these findings. Studies are underway to examine the physiological links of these transcriptomic markers and pathways that lead to susceptibility to altitude illness. Systems biology and human integrative physiological responses to hypoxia: We are undertaking studies to link a comprehensive ‘omics’ pathway of oxygen sensing (transcriptomics, epigenetics, proteomics, metabolomics) to physiological responses that serve to improve oxygen transport during acute and chronic hypoxia. At the Altitude Research Center I have mentored 17 junior researchers, ranging from research fellows in Emergency Medicine, Neurology and Pulmonary Medicine to medical students, postdoctoral fellows and undergraduate students. I am active on the Department of Emergency Medicine research council, and mentor an additional six junior faculty on hypoxia research-related topics.

One or more keywords matched the following items that are connected to Roach Jr., Robert

Item Type	Name
Academic Article	Acute mountain sickness and acetazolamide. Clinical efficacy and effect on ventilation.
Academic Article	Sea-level physical activity and acute mountain sickness at moderate altitude.
Academic Article	How well do older persons tolerate moderate altitude?
Academic Article	Clove cigarettes and high-altitude pulmonary edema.
Academic Article	Ventilation during simulated altitude, normobaric hypoxia and normoxic hypobaria.
Academic Article	Acute mountain sickness: increased severity during simulated altitude compared with normobaric hypoxia.
Academic Article	Exercise exacerbates acute mountain sickness at simulated high altitude.
Academic Article	Frontiers of hypoxia research: acute mountain sickness.
Academic Article	Children at high altitude: an international consensus statement by an ad hoc committee of the International Society for Mountain Medicine, March 12, 2001.
Academic Article	The effect of vasodilators on pulmonary hemodynamics in high altitude pulmonary edema: a comparison.
Academic Article	Renal carbonic anhydrase inhibition reduces high altitude sleep periodic breathing.
Academic Article	High altitude cerebral edema.
Academic Article	Cerebral vasoreactivity in Andeans and headache at sea level.
Academic Article	Treatment of acute mountain sickness: hyperbaric versus oxygen therapy.
Academic Article	Consensus statement on chronic and subacute high altitude diseases.
Academic Article	Intracardiac shunting across a patent foramen ovale may exacerbate hypoxemia in high-altitude pulmonary edema.
Academic Article	Measuring mountain maladies.
Academic Article	Optic nerve sheath diameter, intracranial pressure and acute mountain sickness on Mount Everest: a longitudinal cohort study.
Academic Article	Hypoxemia and acute mountain sickness: which comes first?
Academic Article	Acute mountain sickness: pathophysiology, prevention, and treatment.
Academic Article	Ventilation is greater in women than men, but the increase during acute altitude hypoxia is the same.
Academic Article	High-altitude illness.
Academic Article	Acetazolamide in the treatment of acute mountain sickness: clinical efficacy and effect on gas exchange.
Academic Article	Dexamethasone for prevention and treatment of acute mountain sickness.
Academic Article	High-altitude pulmonary edema. Characteristics of lung lavage fluid.
Academic Article	Acute mountain sickness, antacids, and ventilation during rapid, active ascent of Mount Rainier.
Academic Article	Acute mountain sickness in a general tourist population at moderate altitudes.
Academic Article	Arterial oxygen saturation for prediction of acute mountain sickness.
Academic Article	Oral contraceptives, exercise, and acute mountain sickness in women.
Academic Article	Body temperature, autonomic responses, and acute mountain sickness.
Academic Article	Ventilation, autonomic function, sleep and erythropoietin. Chronic mountain sickness of Andean natives.
Academic Article	Early fluid retention and severe acute mountain sickness.
Academic Article	Role of hypobaria in fluid balance response to hypoxia.
Academic Article	Mortality on Mount Everest, 1921-2006: descriptive study.
Academic Article	Effects of hypobaric hypoxia on cerebral autoregulation.
Academic Article	Effects of acetazolamide and dexamethasone on cerebral hemodynamics in hypoxia.
Academic Article	Pro: Headache should be a required symptom for the diagnosis of acute mountain sickness.
Academic Article	Acute mountain sickness, inflammation, and permeability: new insights from a blood biomarker study.
Academic Article	The lung at high altitude: bronchoalveolar lavage in acute mountain sickness and pulmonary edema.
Academic Article	Medical therapy of altitude illness.
Academic Article	High altitude pulmonary edema and exercise at 4,400 meters on Mount McKinley. Effect of expiratory positive airway pressure.
Concept	Altitude Sickness

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Altitude Sickness